In Vivo PK

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Flexible in vivo PK study designs

  • Intravenous, oral
  • Subcutanous, intaperitoneal, intramuscular, intradermal, topical
  • Intranasal, intratracheal
  • Intracolonic

Sampling Methods  

  • Serial sampling

   Tail-vein, saphenous vein 

  • Cathether (jugular, femoral)
  • Heart puncture (terminal)

 Sample types

  • Whole blood, plasma, serum
  • Tissues/organs
  • Excreta (urine, feces)
  • Cerebrospinal fluid (rat)

Type of studies 

  •  Rapid screening studies to access exposure
  •  PK studies to estimate

    disposition kinetics and bioavailability
    dose proportionality
    routes to excretion (metabolic cages)

  •  Customized studies (CSF sampling, intestinal loops)
  •  Single and repeated dosing                                                          

 For further details on the ADME/PK services available at Fidelta, please follow the indicated links or contact us.