In Vitro ADME

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In Vitro ADME

  • High quality and reproducible data
  • Assay controls continuously tracked and included in each assay
  • Rapid turnaround time
  • Flexible assay formats, protocols and reporting templates
  • Assay packages tailored to meet project requirement

Flexible In Vitro ADME study designs

  • Physicochemical Profiling
  • Intravenous, oral
  • Subcutanous, intaperitoneal, intramuscular, intradermal, topical
  • Intranasal, intratracheal
  • Intracolonic

Permeability and Transporters

  • Serial sampling

Tail-vein, saphenous vein

  • Cathether (jugular, femoral)
  • Heart puncture (terminal)

In Vitro Binding assays

  • Whole blood, plasma, serum
  • Tissues/organs
  • Excreta (urine, feces)
  • Cerebrospinal fluid (rat)

In Vitro Metabolism and Drug-Drug Interaction

  • Metabolic stability

Microsomes, S9, Hepatocytes, Recombinant enzymes
Stability in plasma, blood and biorelevant media

  • Extrahepatic Metabolism

Intestinal microsomes and homogenates

  • Non-CYP Mediated Metabolism

Aldehyde Oxidase Reaction Phenotyping

  • Metabolite Identification and Interspecies profiling
  • Reactive Metabolite screening (GSH)
  • DDI

Cytochrome P450 inhibition and MDI using liver microsomes or recombinant CYP enzymes.

For further details on the ADME/PK services available at Fidelta, please follow the indicated links or contact us.