Resources

Throughout our history of operations, we’ve had the opportunity to execute a variety of exciting and complex projects for our Clients.

The nature of our business is based on high degree of trust and confidentiality, however we are always very excited to co-author or contribute to scientific publications which present our work and expertise.

Datasheets

ADME / PK

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Chemistry

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In Vitro Pharmacology

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In Vivo Pharmacology

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Publications

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Clarithromycin inhibits autophagy in colorectal cancer by regulating the hERG1 potassium channel interaction with PI3K Cell Death Dis. 11, 161, 2020 Find out more

Patents

  • 2021 Preparation of heterocyclyl urea derivatives as modulators of tryptophan catabolism useful in treatment of diseases WO2019229464 view details
  • 2021 Preparation of substituted sulfonyl azacycles as modulators of hedgehog (Hh) signalling pathway WO2019043372 view details
  • 2021 Preparation of substituted cyclyl-sulfonamides as modulators of hedgehog (Hh) signalling pathway WO2019043373 view details

Posters

Poster icon Precision-cut lung slices as an in vitro model for testing of novel therapeutic agents
Belamaric D, Cedilak M, Radovanovic V, Banjanac M, Pribolsan L, Erakovic Haber V, Bosnar M
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Poster icon Macrolide inspired macrocycles as a promising templates for challenging targets
Alihodzic S
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Poster icon Translation from mice and cells to humans: GM-CSF and IL-1β as biomarkers of anti-inflammatory activity of azithromycin
Bosnar M, Belamaric D, Cedilak M, Erakovic Haber V
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Blog

Webinars

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In Vivo Pharmacology
Fidelta Webinar – “Immunopathology and preclinical modelling of systemic lupus erythematosus (SLE)”
Anamarija Markota, PhD
Anamarija Markota, PhD Team Leader In Vivo Pharmacology
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      Systemic lupus erythematosus (SLE) is a chronic and relapsing, autoimmune disease characterized by a break-down of self-tolerance that leads to tissue inflammation and multiorgan damage. Mouse models of lupus are not only an indispensable tool for studying lupus immunopathogenesis but also serve as a powerful system for fast screening of new SLE treatments in order to evaluate their safety and efficacy prior to clinical trials. Due to the extensive heterogenicity of clinical manifestations of SLE in humans, each mouse model displays only specific attributes of the human lupus phenotype. The webinar gives an insight into the most commonly used mouse models of SLE, highlighting their similarities and differences and discussing the advantages of using one model over the other and tailoring it for specific needs in preclinical research in the context of our current understanding of the immunopathogenesis of SLE.

      Dr. Anamarija Markota is an experienced scientist and a team leader in the In vivo pharmacology department at Fidelta focusing on immunobiology and in vivo modelling of inflammatory and autoimmune disorders. After obtaining a double MSc degree in Molecular Biotechnology and Bioindustrial Techniques and a PhD degree in Immunology, Dr. Markota conducted postdoctoral research in the field of immune-oncology and immunotherapy. She has three years of experience as a study director in preclinical research, mainly in the field of IBD and SLE.

      Duration 1 hour Date 15:00, 10 June 2021 CEST
      Drug Discovery
      Ardigen webinar – “AI methods in small molecule design.”
      Michał Warchoł, PhD
      Michał Warchoł, PhD Ardigen
      Krzysztof Rataj, PhD
      Krzysztof Rataj, PhD Ardigen
      Tom Coulter, PhD
      Tom Coulter, PhD Selvita
      Steve Price, PhD
      Steve Price, PhD Fidelta
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        Ardigen, a part of Selvita Group, organized a live webinar “AI methods in small molecule design”. The event took take place on Tuesday, June 15, 2021, at 04:00 PM CEST and was be held by experts from three companies from Selvita Group - Ardigen (Dr. Michał Warchoł and Dr. Krzysztof Rataj), Selvita (Dr. Tom Coulter), and Fidelta (Dr. Steve Price).

        They presented and discussed various methods of AI application in drug design: the current state-of-the-art AI models for small molecules, which protein properties can be predicted, and how to generate new molecules for your project.

        Duration 1 hour Date 16:00, 15 June 2021 CEST