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In Vivo Pharmacology

With numerous disease models developed in the past 10 years, and the experience built within the pharmaceutical industries, biotech and academia, our highly professional in vivo pharmacology team supports drug discovery projects, fully integrated with other preclinical disciplines.
The core areas of our expertise are:
  • Inflammation
  • Infection
  • Dermatology
  • Metabolism
  • Oncology.

We apply a comprehensive approach to primary and secondary pharmacodynamic profiling of the compounds to ensure generation of high quality data relevant to human disease. Our in depth expertise in translational biomarker selection and validation gives confidence in the smooth transition of the candidate molecule into the clinic.

Individual efficacy studies or tailored in vivo pharmacology packages can also be provided, to cover specific client needs. A full panel of automated clinical biochemistry, haematology and coagulation analyses as well as histopathology and a range of molecular biology techniques are available to support investigation of the compound efficacy.

In vivo experiments are performed in AAALAC-I accredited State-of-the-Art animal facility with:
  • Continuous AAALAC-I accreditation status since 2008
  • Competent veterinary personnel (with training equivalent to FELASA Category C and D requirements) and highly experienced technicians and hygiene personnel (with training equivalent to FELASA category A and B requirements)
  • Animal related research based on the 3R principles and high performance standards ensuring animal welfare, humane and ethical use of animals in scientific research
  • Ensured ethical review carried out by Institutional Ethics Committee
  • SPF Barrier Unit equivalent to BSL-2
  • Licensed Laboratory Animals Science (LAS) courses equivalent to FELASA Category B and C training requirements.
Our in vivo pharmacology services offer fully characterized models validated with clinically relevant pharmacological controls:

For further details on in vivo models available at Fidelta, please contact us.


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